Airline Tips/Suggestions?

R

I'm not sure if this is the right place or not, so I apologize if it's not.

It's looking like I'm going to have to fly to my masters residency in July (Ohio) instead of driving. I've only been on a plane once, when I was 15 and don't remember too much of it and my little brother was with me.

Does anyone have any tips or suggestions to help calm my anxiety? When is the best time to buy tickets, packing tips, so on. Do they help you if you get lost while at layovers?