Traveling with a 5 month old

Virah
Has anyone traveled by car on a 22 hour drive (Dallas to Los Angeles) with your 5 month old? Please let me know your experience or would you recommend flying instead? I'm planning on going with my parents and my 5 month old daughter but I don't like the idea of having her sit in her car seat for that long. Let me know your personal experience and suggestions/ friendly advice.