daughter is NEVER happy

I have a one year old. She's 15 months. 
She used to be the happiest baby ever. Now, the last 4 months, ALL she does is SCREAM. And I mean scream. 
She screams her head off. In the car, at home, in stores, everywhere. she will not play with ANY toys. She hates to cuddle. She doesn't want held. She barely eats. She's just.. I don't know. I'm to the point where I don't want anymore kids. People keep saying "terrible twos coming early." No, this isn't normal. She's happy when she's stays with her grandma, or anyone else really. But when she's with me.. I think she hates me. 
I give her everything. I play with her, she's on a schedule. When other people are babysitting, she's perfect. Eats, plays, laughs, etc.
But with me, she won't. She's been to a doctor, nothing's wrong with her.. I don't know what to do