help and suggestions when to test?

Ladies, I need help and looking for suggestions. We have been TTC for almost 2 years. I am on 2nd round of Femara+ metamorphin. With meds I usually have my periods every 30 days. 
This time I am 3 days late, I did take preg test when Aunt Flo was due and it was negative. I am really confused when to test again. My stomach is upset all the time (sorry for the details) I just hate the disappointment that follows the negative test. 
So my question is how early/late you knew you were pregnant? Were there any symptoms? 
It's driving me crazy but I hate to keep my hopes up. 
You guys have been great partners in my journey even though I am one of those silent readers. 
Thanks and appreciate all the help 😊