Need some help ladies!

Samantha

Alright ladies so my wife has PCOS and doesn't have a period at all so they put her on straight estrogen and when she started taking it and got her periods it threw me all out of whack. Crazy hormones and messed up my periods. Well she stopped taking it because she didn't like feeling crazy(aka a girl lol) and now we are ttc and she needs to start taking it again but said she would wait until I was pregnant so she didn't mess me up again. My question is because the hormones are so strong could it have any affect on me pregnant such as I miscarry?