This is a long post, I apologize in advance. I have been on this medication for awhile now and it seems to help somewhat. I was also on lamotrigine but stopped that because I am TTC. I am considered morbidly obese (5'4'' weighing 225 pounds on a good day) the heaviest I've ever been was 245 and that was in March of this year. Anyway, I've been working a little harder at trying to lose weight, and now my doctor and I decided I should increase my Wellbutrin dosage from 300 to 400 mg a day to help me a little more. Is there anyone else on Wellbutrin, preferably on a 400 mg dosage that has noticed a significant amount of weight loss? I'm just curious because I've been reading that this is pretty much the only antidepressant that can help you lose weight.