Need Advice!

Has anyone ever had there s/o cope with depression? My husband is very depressed lately. I feel like no matter what I do it doesn’t help. His dad is finishing up chemo for throat cancer and is grandma has been predicted 2 months to live with her stage 4 bone cancer. He is going through a lot right now but nothing I do or say helps. He holds a lot of it in (like a typical man) and sometimes comes out in anger and frustration. Is there any advice on how to help him through this and not harm our relationship?