So on Saturday I became very sick again, vomiting pretty much every half hour from 4pm until 10pm. I was diagnosed with HG a few weeks ago and the doctor prescribed Zofran, but I hadnt been taking it due to some concerns I had about potential birth defects. Anyway, around 10:30 on Saturday I broke down and took one since I didn't want to end up back in the ER and I couldn't even keep water down. I took another dose Sunday morning and then yesterday afternoon I had the WORST constipation of my life and I couldn't even go to work today I am in so much pain. Has this happened to anyone else on Zofran and if so what did you do to feel better? I called my doctor today and left a message but haven't heard back yet. Any suggestions would be helpful, I've never been in this much pain before!