Baby in pain?

My son has been extremely fussy the past few days. He has been sleeping through the night for a while now but just started waking every three hours again. He has had a bit of a stuffy nose for a few days but no fever. He screams bloody murder when I change his diaper and he has a bit of diaper rash that I’ve been slathering Aquaphor on but it doesn’t seem to be helping. Destin just makes it worse. His usual soothing techniques like the swing aren’t really helping either. He just wants to snuggle and even then he’s fussing. Do you think his diaper rash is causing this? Or maybe he has a cold? Or could it be something else? It breaks my heart to see him so unhappy, I just don’t know what to do! My pediatrician isn’t open until Tuesday and I don’t think this warrants an ER visit, but maybe urgent care? What would you mamas do?