Toddler developing allergy over time??

So this is my sons 4th ear infection and he also has a cold.

1st: amoxicillin- no reaction

2nd: honestly can’t remember off the top of my head- no reaction

3rd- cefdinir- allergic reaction so they prescribed him amoxicillin

4th amoxicillin- allergic reaction

The first 3 happened last year with the 3rd one in August. At around 9 this morning my husband noticed what I thought was a really big bug bite, like the size of a golf ball, on his upper butt. I called the nurse advice line and they advised me to take him in to be checked out. When we were leaving the house, I noticed the “bug bite” spread all over his butt cheek. And then at the drs it had spread all over his butt, back, and legs.

Nothing in his life has changed. He’s been wearing the same diapers, same detergent, same soap, same lotion, same food. Literally nothing has changed.

The doctor said he might actually be allergic to amoxicillin or even penicillin and that we need to do an allergy test. 🙃

Anyone else, adult or baby, not have an allergy and then develop one over time? I’m only allergic to bandaid adhesive so I have no idea. And my husband isn’t allergic to anything either.