Friendship advice

Ladies, I need some help. My best friend always "needs space" whenever he thinks we might get in a fight, and I'm sick of it. We're on space right now and I'm just getting more and more frustrated with him. Any idea of what to do? I've been told to just wait for him to come back, then confront him. Other ideas? It's really triggering my depression and my eating disorder and I'm just not sure what to do.