I ovulate on my own and used both on different months but clomid worked better for me then letrozole. last year 6 months without meds ( not pregnant), 4 months on 50 mg clomid ( not pregnant) 3 months letrozole ( not pregnant), then tried 100 mg clomid in the beginning of January. It worked. 🤷 I was about to take a break from ttc'ing. It was stressing me out. Then bam 💥💥💥 Pregnant. I read if you ovulate on your own clomid is better then letrozole but I'd talk to doc about both. 🤷🥰