Long air travel with 3 year old

We will be traveling with our 3 year old son within the next few months. It will be international flights. Most likely 2-4 connections. One of the flights will be at least 9 hours in the air. We will be traveling from Europe to US. It’s not an option to travel or not. So despite the current travel restrictions, we will still be traveling. I have thought it through a lot but I would like to know any and all advice, recommendations, experiences and considerations I may have not thought of.