Painful Twinges in One Breast

I am 9 days past an IUI and 10 days past a 250mg ovidrel injection. I am also taking 2mg estradiol twice a day (vaginally) and 100mg (I think) progesterone at bedtime (also vaginally). I have been having twinges in my lower abdomen all along but today I started having very painful twinges in one of my breast that sort of travel out the nipple. Is this a good sign of pregnancy or can it also be caused by the meds I'm on?