when is enough....enough

I have been trying to conceive for almost 3 years......the heartbreak every month is getting to be to much. after my miscarriage in September im.ready to give up. I am blessed with 3 little boys that I love more than life. I am very very great full I have these munchkins. It was so easy to get pregnant with them...what gives now? wondering if a 4th and final baby just isn't in the cards.