I was hoping anyone who had been on depo could offer some insight. I had my last depo shot in June last year, so it should have worn off and started to leave my system Just over 12 months ago. In December AF returned and over December and January I had 4 periods, then nothing until mid April however then I had another in May and I finally thought it was normal but after my one normal cycle I didn't have anything until August and since then I've again had nothing.