Again? Really?

Okay so.. My step mother in law and father in law go out every Friday night. Mainly to drink. They text me every Friday afternoon to find out if I would be able to watch their child which of course is my husbands brother. I don't mind every once in awhile but it's almost every Friday for the last couple of months. I have my own two kids. Last weekend we took my him on vacation with is for my daughters birthday. I'm running out of excuses. That sounds terrible but I take my kids almost everywhere with us. If it's not kid friendly we usually don't go. 
Am I wrong for always make excuses? I just don't think it's fair to us and it definitely not fair for their child. She just now texted me and I texted my husband and he said no this is getting out of control. But now I'm stuck in a hardship trying to figure out what to say because I just can't simply say no. 
I feel like a terrible person but then again I think this is outrageous that's this is a weekly thing.