female dogs getting into fights

C.
Okay so this isn't pregnancy related or period related but I need help. Recently my Great Dane and my pit pull have been getting into fights. My Great Dane is beating the pit up really bad. The pit is in heat right now and my Dane isn't fixed either so do you think that could be it? The two times it happened someone went out in the backyard and the Dane just attacked out of nowhere. They haven't had any problems up until now and I don't know what to do. 😕 this last fight was bad. She has puncture wounds and gashes all over her body. The Dane is completely fine though. Here's a pic of them. 
This is them together when my pit bull was a puppy still.