How do you know when it is over ?

I love my boyfriend. I've been with him for a year. But I'm scared that it's over. He's not happy, he's depressed but he constantly assures me it's not my fault. And I don't blame him for that but he is constantly letting me down and I've never been so unhappy with him. The thought of breaking up is killing me. I don't want to lose him but I feel like the relationship is coming to a pretty bad end. How do you know when it's over ?