Is it possible for a first/second trimester screening etc... to not catch an abnormality such as Down Syndrome?

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Close friend's baby had Downs at birth. The Dr was crying because she had missed it, even though my friend had skipped genetic testing. Dr said she should have spotted other signs.

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An ultrasound just looks for markers. There's no way to look at DNA unless you have an amnio

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An ultrasound may detect excess fluid around the neck during the first trimester, but without actually testing for Down's syndrome with blood work such a the harmony test or doing an amniocentesis, I don't believe there's anyway for an ultrasound alone to determine Down syndrome.

Is it possible for a first/second trimester screening etc... to not catch an abnormality such as Down Syndrome?

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