I just want the screaming to stop

As

my daughter is now 6 weeks old and for weeks now at night between midnight and 4am she will be up screaming crying for hours nothing I'm doing works I try nursing swaddling laying her every which way and she is still crying. she had a doctor's appointment yesterday and she is doing amazing as far as her weight and length I'm at wits end not to mention I have a 18 month old too who's up early every morning. what can I do to help her? is it colic? I just want my baby to stop crying