My question is can Depo shot change my cycle and could it be my cycle is doing down and back to normal? Can depo shot change your cycle once you get off it. I got my first shot on Dec (6th) I was supposed to go back in March and get my next shot but I didn't. So march 10th I received my period (didn't have one for 3 months of bc). March to April it was a 33 CD, April to May it was a 31 CD and now May to June is a 30 CD. I've been ttc since March. please I need help ladies.