Can the depo shot make you moody? I have been on it for a few months now and I just feel off alot. Like my boyfriend can be doing something and out of no where I'll get annoyed with him and it will just ruin my mood for the whole night. I love him I do, but I just don't know why I am like this towards him? Could it be because of the shot or is there something else that could be causing this? I don't know... I have just been feeling kind of down lately and I don't know what to do.