Estradiol symptoms : sore nipples?

My husband and I have been TTC for almost 2 years. This was my third <a href="https://glowing.com/glow-fertility-program">iui</a> and had used clomid; they saw I had 4 egg follicles. I felt cramping a day or two after <a href="https://glowing.com/glow-fertility-program">iui</a>, assumed it was ovulation cramping. I did do the trigger shot. They also started me on estradiol (estrogen) to thicken my lining. About 6-7 days after <a href="https://glowing.com/glow-fertility-program">iui</a> I felt cramping again. No blood, thought maybe implantation? I then got very sore nipples. A week later my nipples are still sore, but no other symptoms other than extremely hormonal. I’m stopping the estradiol and my first two pregnancy tests were negative. I expect my period in about 2-3 days. Thoughts? Feeling so hopeless after almost 2 years .