2 month immunizations

My daughter got her immunizations this morning and was fine the entire day other than her thighs being a little swollen. Then come night time, though she's sleepy, she cries out randomly and can't get comfy. The first time we gave her the Tylenol the Dr prescribed and it seemed to relax her a bit so we gave it to her again just now since its been well over 4 hours since she last had it. But is that normal for it not to really affect her and make her uncomfortable until the night time?