My baby girl was constipated for 3 days when she was 2 weeks old. On the 4th day, I decided to take her to her pediatrician. He prescribed suppositories and they did not work. So on the 5th day, after searching online for another solution(besides the q-tip solution), I went out and bought Enfamil Reguline. After giving her a bottle of the Reguline, she immediately pooped. It was green and runny but she was no longer constipated. Definitely recommend this formula if any moms can't seem to find an answer.