An endometrial biopsy involves taking a small tissue sample from your uterus. Lab technicians looking at this tissue can identify problematic cells, changes in hormone levels, and infections that may prevent an egg from implanting in your uterus.

What the Test Involves

You will be asked to remove your clothes from the waist down and given a medical gown. A small tool, or speculum, is inserted into the vagina to open the area. Your cervix may be numbed with a spray or local anesthesia. Then, a small tool is used to collect a sample of your uterus tissue. You may feel some cramping while this is done.

You may have light bleeding and soreness for a day or two after the exam, and discharge is normal for up to a week after the biopsy.

Tips & Hints

You will be asked to have an empty bladder for this biopsy, and you should refrain from using tampons or any vaginal medicines leading up the the procedure. However, after the procedure, you may want to use a panty liner for up to a week in case you have any spotting. Do not have sex or use tampons until spotting stops.

Your doctor may recommend you take pain reliever beforehand to alleviate discomfort during the exam. If no prescription or over-the-counter medicine is suggested to you and you’re concerned about pain, ask about it at least a day before so you have time to pick up the medicine and take it as prescribed before the test.

Endometrial biopsy is one of a series of tests involved in the infertility workup evaluating a patient for treatment.