Thinking about taking a break

I’ve gone from Clomid with Ovidrel and TI to Femara with Ovidrel and TI (miscarriage) to Femara with Ovidrel and <a href="https://glowing.com/glow-fertility-program">IUI</a> x2 starting in June. Unexplained infertility. Been trying since July 2016. I’m thinking about taking a cycle off. Has anyone done this and had success? If yes did you use OPK’s or anything? Did it screw up your cycle?