Newbie question...cotton spandex!?

Noradun • 🌸Due in Sept 2019 with 🌈 after TTC 3.5 yrs with PCOS👣Mommy of 5 💑 Married for 14 yrs👩🏼‍🎓Graduating in 2019 👩🏼‍💻 WFH Mom 🌼

So I love the fee of cotton spandex, the stretch is nice too, but the feel just is a biggy! I am semi new to sewing and I am still learning fabrics and what can/should be done with them!! If I wanted to make a blanket, could I potentially use stretch fabric on one side an a not stretch on another, for example the cotton spandex on one side and cotton quilting fabric on the other or is that just stupid?