My first obgyn is Nov 2nd and i called yesterday to ask this and was told it "should be fine" but looking for other opinions. I took ibuprofen pm for sleep and knee pain (i run 3-6mi 3× a week) before i got pregnant. I am taking benadryl since i dont sleep without something...even now i am here awake at 3:45am. I just can't help but wonder is it going to have a negative impact!