My wife has no friends

This Is going to be a long one

 We live in a small town and for the last few years, my wife and I haven't had much of a social life. Its something that really gets to her. When she was in high school she was on several sports teams and was always surrounded by friends. When she started college, she didn't make any friends in her classes and stopped playing basketball after one semester because she couldn't mesh with her team. She had a few friends through work, but then she was fired from that job and didn't see them anymore because we lived about 20 minutes away in the next town over. 

She never really gelled with coworkers in her  any of the jobs following that and hasn't made any friends in a few years. Because of this, she doesn't feel like she gets to do "typical 22 year old things" like go to parties, go out to clubs or bars, brunch with friends (We are pretty broke.right now and can't really afford all that going out anyways) and all that good stuff. She feels like she's wasting her twenties. She recently had a birthday and cried because she didn't have any friends to celebrate with her or make  her feel special. This is something she cries about and gets down on herself about A LOT. 

I don't know how to help because I cannot relate. When I was in high school, I struggled with depression and never had a lot of friends. Towards the end, I went on independent studies (meaning I didn't do school on campus and never interacted with any other students) and spent everyday alone because everyone I knew was actually in school. I had no other choice but to learn how to be comfortable being alone and I got used to it pretty easily. Over the years I did end up making friends, but I never felt like I needed them. I hold the friends I do have very near and dear but they know not to count on me to go out with them. Unlike my wife, I make friends easily. I just don't wanna. I am more than okay spending everyday alone or with my cat. I don't like going to bars, I don't like clubs, I got all my partying out my first year of college. Socializing all day with coworkers is all the socialization I need outside of my marriage. 

So helping my wife be okay with not having friends is really difficult. Its hard comforting her about the same thing she's been crying about for THREE years. At this stage in my life, the only way I can think to make friends is through work. Unfortunately, she works out in the field with only one other person, who is a married man in his 50's. So I don't know if he is going to be her new bestie. 

I don't have friends in the town we live in, so it can't be a "my friends are her friends" kind of situation. 

We have a bunch of friends we see at raves, but we don't see them outside of raves because they're all so scattered and live at least an hour away from us (most live 2+ hours away)

I want to just look at her and tell her to get over it, but for OBVIOUS reasons I can't lol. I know its important to have friends, but I can't magically build her a social life. I hate seeing her cry and I don't know what to do. What do you guys think?