Long drive with baby

Hailey • Mother of 3 amazing children! 👦 03/04/10 👧 04/29/12 👶 01/07/16 ❤️️
On April 1st I will be taking my then 12 week old (10 weeks tomorrow) and my two other children (6&3) to visit my parents 2 hours away.
My 10 week old has borderline colic, and the second we put him in his carseat he screams until I take him out, literally. I'm dreading this drive, which will be the first time he's driven anywhere longer than 20 minutes, can anyone give me some advise on to make the drive as easy on him and us as possible?? (Other than the obvious, full stomach, clean diaper etc.)
Thank you!!