Constipated. :(

I am so constipated and I don't know what to do. It's making me so tired, lethargic and nauseated. I'm having a hard time even eating because of my lack of appetite. I've tried stool softeners and the occasional enema but the relief has been marginal at best. I've been experiencing this since Wednesday. 😔 Do you ladies have any safe suggestions? When should I see a doctor?