Need advice about parents/in laws

So I'm a FTM and we live in a different state than both my parents and my in laws. I am super close with my parents, and fine with my in laws. We live in a 2 bedroom home and the second bedroom is now our nursery. It does have a guest bed in there but I really don't want my in laws staying in there since I will need to be in and out of there with the baby once he arrives. (His changing table, clothes, glider etc) would it be horribly wrong for me to ask them to stay in a hotel when they come visit? I don't want to seem rude but I also want to be able to use my nursery and wth guests in there it would be uncomfortable? Also would I have to ask all parents to stay in a hotel, even though I wouldn't mind my parents in there but not in laws?