HELP... Advice??

I'm 16 and for the past couple months, I've been feeling very different. Nearly everything aggravates me. I really want to try new things, join clubs, lose weight and get healthy, grow my relationship with God. My best friends and I been together for nearly 7 years but now I can't stand to be around them. One of them always lies and cancels plans and the other always thinks she's knows what's best and is very clingy even though I asked her repeatedly to stop. What should I do about them and my life?? Please comment any advice!