Powder vs Ready made formula

Has anyone noticed a difference in their babies spitting up more/less on powder vs ready made? My LO was having constipation issues so our ped switched us to Similac Total Comfort (purple can). The switch has helped a ton with the constipation but now he spits up with just about every bottle and throws up at least once a day (projectile vomiting from a tiny human is not fun). He burps great at least twice in a 3 oz bottle and we keep him upright for 30-45 min after feedings. I’m just curious if ready to feed would ease the spitting up/vomiting any.