Advice When Best Friend is Rude

So, I have had some major health issues that makes pregnancy a no go currently. I just turned 38 in April. I have one daughter. I am hoping that I get the all clear in September/October to try for baby 2. One of my really good/best friends who knows my struggle is done having kids she’s just turned 40 soon to be 41 in September. She herself cannot have any more nor does she want more. She has two her youngest is 10. She’s always making comments about how she can’t understand anyone who would have a baby at 40. “Omg what is wrong with people to have a baby at 40! No thank you! I can’t nor would I want to deal with what I had to in my 20’s!” Mind you I myself had my first child at 35 so again... she’s low key dissing me. I don’t know if she even knows she’s doing it or that it hurts me but I’ve cried to her about 4 times this year because I’m unable to have one at this time due to my meds and physical condition. I just keep quiet and ignore she’s a loud mouth as well so it’s hard to get a word in edgewise sometimes. Should I tell her how I feel or just ignore it. She’s not malicious, she is abrasive and she does say shit without thinking majority of the time. But, know your audience right?! .... frustrated.