I think my friend is ignoring me.

So I last saw my friend on Christmas break. And the last couple times before that she just seemed off. She said she’s just tired or depressed. The last time I saw her things where ok she got kinda annoyed with me bc I reminded her we had to go to the store. Well she was sick last week and I have messaged her a couple of times to see how she’s doing and she reads it and doesn’t say anything. She always posting stuff of fb so idk if she’s just going through her own thing or if she’s just annoyed with me. It’s not like her to just ignore me.

Should I try to reach out again sometime or just wait for her.