If you have bipolar disorder what medication/medication combos worked best for you and what worked the least for you? Currently on Effexor and abilify and they just aren’t working for me anymore. I also have tried Zoloft and olanzapine. Zoloft didn’t work at all and olanzapine worked for awhile but started turning me into a zombie. I’m just so frustrated trying to find something that works. I’ve been so depressed lately, I don’t want to get out of bed, go to work, clean, or anything. I’m just at a loss and want to give up. 😔