Ughhh heartburn!

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Is it just me or is there anyone else out there suffering from horrible heartburn every minute of the day and night? I'm literally never without it. It's so bad I throw up from it and Listerine has became my new best friend that I never leave home without! I've tried the medicine my Ob prescribed, vinegar remedies, even baking soda and water shots do not help. I only drink water all day every 30 minutes an 8oz glass goes down and nothing works... Help!?: please?