Weight loss pills & other products

I've struggled with my weight for years and have a really really hard time trying to lose it; it's all over the place from PCOS. Has anyone tried weight loss pills, smoothies, ect and had good results? Every time I see the Slim Quick commercial, the more I wonder if it and stuff like it works.

*Posting anonymously because I'm embarrassed and my sister is on here.

Edit #1: I should mention that I have done diets before and they usually don't work because I can't follow the eating schedule. In addition to metformin and synthroid, I have 2 other medications that I take every 6 hours and I have to eat something with them. My stomach is so sensitive that any rx or otc med I take, even Tylenol or a prenatal, has to be take with food or I get sick. I'll usually eat yogurt or cottage cheese for the midnight dose.