Consistent BFN - in the family?

Laura
My mom told me she never got positives with home pregnancy tests with any of her four pregnancies (1 that was ectopic). She had to demand a blood test. Luckily she did, because the ectopic pregnancy could have killed her (and doctors didn't believe she was pregnant because the urine tests were negative). Is this something that can run in the family? Anyone have experience with this?