Seperation Anxiety

My 6 month old SCREAMS if I leave her for any amount of time. She's ok with my husband half the time. I left her with my mom today and she screamed almost the whole time I was gone. Snot, tears, the works. At our Christmas, she won't let anyone hold her even if I am touching her. I am a stay at home mom, it's just her and I all day since birth. We see friends and relatives about 1x a week. Any advice at all would be so helpful, I'm desperate!