When should I see a doctor?

Allison

My period is currently 5 days late. I usually have 36-40 day cycles, today is CD45. I have taken 2 pregnancy tests and both came out negative. I have very light brown spotting that is only present when I wipe. I’m still waiting for AF to come, but am wondering when I should call my doctor to make an appointment. (PCOS and Ovarian tumors are common in my family)