Does anal really lead to a lot of diseases even when using protection?

So my grandma and I are extremely close, so one day when she found out I was having sex she told me to never have anal sex because it's disgusting and can lead to diseases. She's very old fashion, so she thinks kissing, oral, and anal are all gross. She's a germaphobe. I was just wondering if she is overreacting again or if this is true.

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