Zofran- Safe or no?

Audrey
Ok ladies- this is my third pregnancy and while I am blessed that I rarely vomit while pregnant the nausea I've had this time has been crippling. My husband has to work a lot and I have two toddlers to care for. My midwife prescribed me Zofran but I've heard controversial things about it. What is YOUR experience with this Rx??? 
Thanks!
(I'm considering the Unisom/B6 combo instead but I'd possibly have to wean my youngest early and he's just not ready yet. Trying to weigh my options here!)

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