Setting Boundaries with the In Laws??? HELP PLEASE!

My husband and I have been married two years, and we have just loved our lives together! We have talked about having a family for a while, and finally decided that now is the right time. One of the reasons I had for putting it off was that my in laws, particularly my MIL is a huge control freak, and we don't see eye to eye on very much. I feel as though she is trying to run our lives and control my husband and I as if we were babies, and I don't want that toxic relationship making me feel guilty when it comes to me having a baby.

We currently live in the same town and see them almost every weekend, but the second we go to MY parents house for a day or two she throws a fit and tries to guilt trip us for leaving them. Now that we are TTC, my husband and I have really wanted to have a conversation about boundaries. She still is unhappy with the idea of us moving away in a few months and tries to make us feel guilty for beginning careers and getting a home and family away from them (but I can't think of anything better!). She tells us we are making the wrong choices and hurting those we love.

How can we have a positive conversation that sets some clear boundaries? She has been driving me crazy and now I really know it's time for my husband and MIL to have a heart to heart. I know having a grandbaby will complicate these feelings so I want to deal with it before it happens.

JUST FYI, my MIL is also has some physical disabilities and depression that I think play into this. She is lonely, but she will also be so unkind and I feel so hurt that she doesn't value our choices or my family enough to give us autonomy. Any ideas of what to say without being rude or mean?