Would you be upset if your best friend had sex with your younger sibling?

I’m in the middle of this issue. My brother (23) is really upset with his friend (also 23) and our little sister (18) because they apparently had sex the other night. They were drinking and smoking together with a few other people. My brother and my sister live with our parents still and the friend lives there as well. They frequently all hang out together and they were that night too. That night they ended up having sex and I guess my brother kind of thought that’s what happened and asked and now he’s really annoyed and not really talking to either of them. Our sister is kind of wild like that so it really doesn’t surprise me so I’m not phased by it at this point. But I’m wondering if I should tell my brother to get over it or if his actions and feelings are valid