Can progesterone cream cause bad cramps in early pregnancy ?

I’m 4 weeks 1 day and I’ve been having intense cramps for the past 2 days. Wakes me at midnight and I won’t sleep till morning. The only thing I know I do is take progesterone cream and take nature made prenatal.called my doctor’s office and they won’t be able to see me till next week. I’m worried because I’ve had 2 consecutive miscarriages that starts with cramps.