I have a van with captain seats and a full bench third row.  I'll probably put one of my older ones in the third row and the baby in one of the captain seats.  It's going to be work getting all those babies out of the car!

Babies are safest in the middle but if you can't get them in and out you may not have a choice!!

Depends on how it will work in my car either in the middle or behind the passanger side.